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Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance

✍ Scribed by Jian Sun, Yixi Luo, Zhen Tian, Liang Gu, Shu Chi Xia, Youcheng Yu

Book ID
119897533
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
525 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Abstract Ebp1, an ErbB3 binding protein and downstream effector of the ErbB signaling network was shown to be a potent tumor suppressor in breast and prostate adenocarcinomas. We hypothesized that the inhibitory properties of the __ebp1__ gene could also be beneficial if ectopically expressed in

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## BACKGROUND. Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary gland origin. It tends to grow slowly but shows frequent recurrence and metastasis, ultimately with a poor outcome. Reduced expression of a cyclin-dependent kinase inhibitor, p27 Kip1 , has been reported to correlate wit