✦ LIBER ✦

Reduced expression of p27Kip1 protein in relation to salivary adenoid cystic carcinoma metastasis

✍ Scribed by Takashi Takata; Yasusei Kudo; Ming Zhao; Ikuko Ogawa; Mutsumi Miyauchi; Sunao Sato; Jun Cheng; Hiromasa Nikai

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 150 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990915)86:6<928::aid-cncr6>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary gland origin. It tends to grow slowly but shows frequent recurrence and metastasis, ultimately with a poor outcome. Reduced expression of a cyclin-dependent kinase inhibitor, p27 Kip1 , has been reported to correlate with poor survival for patients with various types of carcinoma. However, there has been no previous study reported of p27 Kip1 expression in ACC, to the authors' knowledge.

METHODS.

To evaluate p27 Kip1 as a prognostic marker, the authors examined the immunohistochemical expression of p27 Kip1 protein in 29 ACCs and correlated its expression with clinicopathologic findings. Eleven pleomorphic adenomas (PAs) were also examined to compare the p27 Kip1 expression in benign and malignant salivary gland tumors.

RESULTS.

All PAs expressed p27 Kip1 at high levels, whereas 83% of ACCs (24 of 29) showed reduced expression of this protein. Furthermore, the expression levels were significantly lower in ACCs with metastasis than in those without metastasis.

The authors also examined the expression of p27 Kip1 in 2 ACC cell lines (ACCh and ACC3) by Northern and Western blot analysis to elucidate the possible mechanism of p27 Kip1 reduction in ACC. Both ACCh and ACC3 expressed p27 Kip1 mRNA, but ACCh did not produce p27 Kip1 protein. In ACCh, the expression of p27 Kip1 protein was induced by treatment with a proteasome inhibitor.

CONCLUSIONS.

Overall, these findings suggest that reduced expression of p27 Kip1 may correlate with the development and progression of salivary ACC and can be an indicator of its malignant behavior. They also suggest that increased proteasomemediated degradation may play an important role in this reduction of p27 Kip1 expression.

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