Expression of delta-like 1 homologue and insulin-like growth factor 2 through epigenetic regulation of the genes during development of mouse molar
β Scribed by Qalb-E-Saleem Khan; Amer Sehic; Natalie Skalleberg; Maria A. Landin; Cuong Khuu; Steinar Risnes; Harald Osmundsen
- Book ID
- 114797399
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 774 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0909-8836
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## Abstract Insulinβlike growth factorβ1 (IGFβ1) is essential to hippocampal neurogenesis and the neuronal response to hypoxia/ischemia injury. IGF (IGFβ1 and β2) signaling is mediated primarily by the type 1 IGF receptor (IGFβ1R) and modulated by six highβaffinity binding proteins (IGFBP) and the
Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objec