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Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers

✍ Scribed by James H. Kim; Mark E. Sherman; Frank C. Curriero; F.Peter Guengerich; Paul T. Strickland; Thomas R. Sutter


Book ID
113923256
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
495 KB
Volume
199
Category
Article
ISSN
0041-008X

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Expression of CYP1A1, CYP1B1 and CYP3A,
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Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3