## Abstract The expression of nine oncogenes (cβmyc, Nβmyc, Nβras, Hβras, kβras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC/PRF/5, HepSB, Hep G2, 2.2.15, HLE,
Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
β Scribed by Hironori Koga; Shotaro Sakisaka; Masahito Ohishi; Takumi Kawaguchi; Eitaro Taniguchi; Kurumi Sasatomi; Masaru Harada; Taku Kusaba; Masatoshi Tanaka; Rina Kimura; Yutaka Nakashima; Osamu Nakashima; Masamichi Kojiro; Toshihiko Kurohiji; Michio Sata
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 898 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-9139
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## Abstract ## BACKGROUND Cyclooxygenaseβ2 (COXβ2) seems to be involved at various steps in the processes of malignant transformation and tumor progression. Investigations have shown that COXβ2 overexpression is associated with increased proliferation, reduced apoptosis, and angiogenesis. ## METH
Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transp