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Expression of cyclin E in dysplasia, carcinoma, and nonmalignant lesions of barrett esophagus

✍ Scribed by Mario Sarbia; Nuran Bektas; Wolfram Müller; Hansjörg Heep; Franz Borchard; Helmut E. Gabbert

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
254 KB
Volume
86
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Barrett esophagus (BE) is a condition in which the normal squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium. BE is a premalignant lesion because it is the initiating factor in a metaplasiadysplasia-carcinoma sequence.

METHODS.

Expression of the proliferation-associated molecule cyclin E was immunohistochemically determined in metaplastic specialized epithelium (SE; n ϭ 24), low grade dysplasia (LGD; n ϭ 21), high grade dysplasia (HGD; n ϭ 17), and invasive adenocarcinoma (CA; n ϭ 35) from 36 esophagectomy specimens. In addition, endoscopically obtained samples of SE with minimal inflammatory changes (n ϭ 11) and SE adjacent to erosions or ulcerations were tested for cyclin E expression.

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