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Prognostic value of cyclin E and p53 expression in gastric carcinoma

✍ Scribed by Teruyuki Sakaguchi; Akihiko Watanabe; Hidetomo Sawada; Yukishige Yamada; Jun Yamashita; Masahiko Matsuda; Masakazu Nakajima; Takeshi Miwa; Tomoko Hirao; Hiroshige Nakano

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
236 KB
Volume
82
Category
Article
ISSN
0008-543X

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✦ Synopsis

With regard to prognosis, patients whose tumors had both First Department of Surgery, Nara Medical Unistrong positivity for cyclin E and positivity for p53 had significantly poorer prognosis. versity, Nara, Japan.

In multivariate analysis, the combined variable of cyclin E and p53 was an independent prognostic indicator together with serosal invasion and tumor size.

CONCLUSIONS.

These data suggest the cyclin E expression correlates with p53 expression and may contribute to the progression of gastric carcinoma. The combined variable of cyclin E and p53 expression could be a useful prognostic indicator in patients with gastric carcinoma.

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