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Expression of cell surface P-glycoprotein by an Adriamycin-resistant murine fibrosarcoma

✍ Scribed by Raffaella Giavazzi; Norbert Kartner; Ian R. Hart

Publisher: Springer
Year: 1984
Tongue: English
Weight: 297 KB
Volume: 13
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00257134

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✦ Synopsis

Analysis of the cell membrane of Adriamycin (doxorubicin)-resistant UV-2237 ADMR murine fibrosarcoma cells revealed a 170,000-dalton component that is not found in the drug-sensitive parent or revertant cells. Immunoblot (Western blot) analysis showed that this component is similar to the 170,000-dalton P-glycoprotein found on the surface of Chinese hamster ovary cells that exhibit multidrug resistance. Thus, multidrug resistance and P-glycoprotein expression apparently can occur in a wide variety of cells, including the metastatic murine solid tumor cell line described here.

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