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Expression of cell regulatory proteins in ovarian borderline tumors

✍ Scribed by Caroline van Haaften-Day; Peter Russell; Cinda M. Boyer; Billie-Jo M. Kerns; Jon R. Wiener; Debra N. Jensen; Robert C. Bast Jr.; Neville F. Hacker

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
616 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND.

Tumors of borderline malignancy are still a controversial subgroup of ovarian neoplasms. The expression of several cell regulatory proteins was studied to characterize the molecular phenotype of these tumors, and to compare them with their benign and malignant counterparts. METHODS. Specimens from 22 patients with tumors of borderline malignancy (1 1 serous and 11 mucinous tumors), 12 patients with benign tumors, and 16 patients with invasive ovarian carcinomas were evaluated for expression of epidermal growth factor receptor (EGFR), HER-2/neu, PTPlB, and p53 by immunohistochemical techniques.

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