## Abstract Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors. The __BLU__ gene, located at 3p21.3, has recently been identified as a
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
β Scribed by Paulisally Hau Yi Lo; Alfred Chi Chung Leung; Wenjun Xiong; Simon Law; Fuh-Mei Duh; Michael I. Lerman; Eric J. Stanbridge; Maria Li Lung
- Book ID
- 116333718
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 571 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0304-3835
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Chromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth __in vivo__ by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was
## Abstract ## Background We modified a tetracyclineβregulated system that can control the activity of individual genes quantitatively and reversibly in transgenic mammals. Despite these advances, there remained one problem in the intensive use of the tetβsystem: the limited range of acceptor cell
To help define the location of tumour suppressor genes implicated in the pathogenesis of oral squamous cell carcinoma (SCC), we have used microsatellite assay and restriction fragment length polymorphism (RFLP) analysis to screen 48 primary SCC for allelic imbalance (AI) with 32 polymorphic markers