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Expression of Bruton's tyrosine kinase in B lymphoblastoid cell lines from X-linked agammaglobulinaemia patients

โœ Scribed by M. DE WEERS; G. M. DINGJAN; G. S. BROUNS; M. E. M. KRAAKMAN; R. G. J. MENSINK; R. C. LOVERING; R. K. B. SCHUURMAN; J. BORST; R. W. HENDRIKS


Book ID
108698684
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
258 KB
Volume
107
Category
Article
ISSN
0009-9104

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## Mutations in the Bruton's tyrosine kinase (BTK ) gene are responsible for X-linked Agammaglobulinemia (XLA), an immunodeficiency caused by a block in B cell differentiation. Non Isotopic RNAse Cleavage Assay (NIRCA), followed by sequencing was used to screen for BTK mutations in 11 Italian XLA p

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Mutations in the Bruton tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA), which is characterized by recurrent bacterial infections, profound hypogammaglobulinemia, and decreased numbers of mature B cells in the peripheral blood. We evaluated 17 male Brazilian patients