## Mutations in the Bruton's tyrosine kinase (BTK ) gene are responsible for X-linked Agammaglobulinemia (XLA), an immunodeficiency caused by a block in B cell differentiation. Non Isotopic RNAse Cleavage Assay (NIRCA), followed by sequencing was used to screen for BTK mutations in 11 Italian XLA p
โฆ LIBER โฆ
Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing
โ Scribed by K-W. Chan; T. Chen; L. Jiang; S. F-S. Fok; T-L. Lee; B-W. Lee; X. Yang; Y-L. Lau
- Book ID
- 114831349
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 67 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1744-3121
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Mutations in the Bruton tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA), which is characterized by recurrent bacterial infections, profound hypogammaglobulinemia, and decreased numbers of mature B cells in the peripheral blood. We evaluated 17 male Brazilian patients
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