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Expression of Bone Morphogenetic Protein-2 via Adenoviral Vector in C2C12 Myoblasts Induces Differentiation into the Osteoblast Lineage

✍ Scribed by Yasunori Okubo; Kazuhisa Bessho; Kazuma Fujimura; Tadahiko Iizuka; Shin-Ichi Miyatake

Book ID: 115584380
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 304 KB
Volume: 262
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1999.1281

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## Abstract Previous studies have shown that osteogenic protein‐1 (OP‐1; also known as BMP‐7) induces differentiation of the pluripotent mesenchymal cell line C2C12 into osteoblastic cells. OP‐1 also alters the steady‐state levels of messenger RNA (mRNA) encoding for the cartilage‐derived morphogen