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Expression of BCR–ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia

✍ Scribed by Manu Gupta; Lili Milani; Monica Hermansson; Bengt Simonsson; Berit Markevärn; Ann Christine Syvänen; Gisela Barbany

Book ID
116296118
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
189 KB
Volume
366
Category
Article
ISSN
0006-291X

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## Abstract Jab1, a co‐activator of AP‐1 transcription factor and the fifth subunit of the COP9 signalosome, mediates degradation of the tumor suppressor p53 and p27^Kip1^ and functions as a tumor promoter in different types of human cancer. In this study, we show that inhibition of Bcr‐Abl oncogen