𝔖 Bobbio Scriptorium
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Expression of BCR – ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation

✍ Scribed by Cambier, N; Zhang, Y; Vairo, G; Kosmopoulos, K; Metcalf, D; Nicola, N A; Elefanty, A G


Book ID
110061760
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
525 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Jab1, a co‐activator of AP‐1 transcription factor and the fifth subunit of the COP9 signalosome, mediates degradation of the tumor suppressor p53 and p27^Kip1^ and functions as a tumor promoter in different types of human cancer. In this study, we show that inhibition of Bcr‐Abl oncogen