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Expression of bcl-2 inhibits necrotic neural cell death

✍ Scribed by D. J. Kane; T. Örd; R. Anton; Dale E. Bredesen

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
966 KB
Volume
40
Category
Article
ISSN
0360-4012

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✦ Synopsis

Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcE-2 does not inhibit the cellular death program directly; rather, bcl-2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others.

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