Overexpression of Bcl-2 or Bcl-xL prevents spiral ganglion neuron death and inhibits neurite growth

Interaction of neurotrophin signaling wi

Interaction of neurotrophin signaling with Bcl-2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growth

✍ John P. Renton; Ningyong Xu; J. Jason Clark; Marlan R. Hansen 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 625 KB

## Abstract Enhanced spiral ganglion neuron (SGN) survival and regeneration of peripheral axons following deafness will likely enhance the efficacy of cochlear implants. Overexpression of Bcl‐2 prevents SGN death but inhibits neurite growth. Here we assessed the consequences of Bcl‐2 targeted to ei