Expression of Bcl-2 family of proteins in fresh myeloma cells
β Scribed by Harada, N; Hata, H; Yoshida, M; Soniki, T; Nagasaki, A; Kuribayashi, N; Kimura, T; Matsuzaki, H; Mitsuya, H
- Book ID
- 110053988
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 100 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival an
REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens. Those most similar to Bcl-2 promote cell survival by inhibiting adapters needed for activation of the proteases (ca