Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration
β Scribed by Maria Concetta Geloso; Valentina Corvino; Valentina Cavallo; Amelia Toesca; Enrico Guadagni; Roberto Passalacqua; Fabrizio Michetti
- Book ID
- 116766314
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 223 KB
- Volume
- 357
- Category
- Article
- ISSN
- 0304-3940
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In situ hybridization and immunocytochemistry were applied to investigate changes in the expression of somatostatin, neuropeptide Y, neurokinin B, cholecystokinin, dynorphin, and Met-enkephalin in the rat hippocampus after administration of a single peroral dose of trimethyltin hydroxide (9 mg/kg).
## Abstract Adult SpragueβDawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks aft