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Trimethyltin-induced expression of GABA and vimentin immunoreactivities in astrocytes of the rat brain

โœ Scribed by Dr. Helena Andersson; Johan Luthman; Lars Olson

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
632 KB
Volume
11
Category
Article
ISSN
0894-1491

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โœฆ Synopsis

Abstract

Adult Spragueโ€Dawley rats were given a single dose of trimethyltin chloride (TMT). Three days following treatment, a neuronal alteration was observed in the CA3c pyramidal cell layer of hippocampus which was not accompanied by any apparent astrocyte reaction. At 1 as well as 2 weeks after treatment, a gliosis in hippocampus, piriform, and entorhinal cortices was detected by glial fibrillary acidic protein (GFAP) immunohistochemistry. Concomitant with the enhanced astrocytic GFAP, astrocytes were swollen and expressed immunoreactivity to vimentin and ฮณโ€aminobutyric acid (GABA). The astrocytic GABA immunoreactivity may reflect a trimethyltinโ€induced alteration in astrocyte phenotype, or alterations in compartmentalization and/or metabolism of GABA. ยฉ 1994 Wileyโ€Liss, Inc.

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