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Expression of abnormal transcripts of the FHIT (Fragile Histidine Triad) gene in ovarian carcinoma

โœ Scribed by M Mandai; I Konishi; H Kuroda; K Nanbu; K Matsushita; Y Yura; A.A Hamid; T Mori


Book ID
117664210
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
193 KB
Volume
34
Category
Article
ISSN
0959-8049

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## Background: The fragile histidine triad (fhit) gene is a tumor suppressor gene that belongs to the histidine triad family of nucleoside binding proteins. the gene encompasses the common human chromosomal fragile site, the fra3b locus at chromosome 3p14.2, and is expressed in most normal adult ti

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## BACKGROUND. Human papillomaviruses (HPV) are the most important etiologic factor for cervical carcinoma. However, additional cellular events may be necessary for malignant progression in the cervix. Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was