The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. FHIT has been suggested to be a candidate tumor suppressor gene for digestive tract carcinomas. To ev
โฆ LIBER โฆ
Altered Expression of the Fragile Histidine Triad Gene in Primary Gastric Adenocarcinomas
โ Scribed by Sang-Han Lee; Woo-Hyoung Kim; Hyun-Kyoung Kim; Kee-Min Woo; Hae-Seon Nam; Hong-Soo Kim; Jin-Gook Kim; Man-Hee Cho
- Book ID
- 115588107
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 109 KB
- Volume
- 284
- Category
- Article
- ISSN
- 0006-291X
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## BACKGROUND. The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers. Replacement of the FHIT gene into cancer cell lines lacking FHIT expression results in loss of tumorigenicity and tumor growth. METHODS. We investigated the status and function of the FHIT gen
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