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Altered Expression of the Fragile Histidine Triad Gene in Primary Gastric Adenocarcinomas

โœ Scribed by Sang-Han Lee; Woo-Hyoung Kim; Hyun-Kyoung Kim; Kee-Min Woo; Hae-Seon Nam; Hong-Soo Kim; Jin-Gook Kim; Man-Hee Cho


Book ID
115588107
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
109 KB
Volume
284
Category
Article
ISSN
0006-291X

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The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. FHIT has been suggested to be a candidate tumor suppressor gene for digestive tract carcinomas. To ev

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## BACKGROUND. The fragile histidine triad (FHIT) is frequently deleted and altered in many human cancers. Replacement of the FHIT gene into cancer cell lines lacking FHIT expression results in loss of tumorigenicity and tumor growth. METHODS. We investigated the status and function of the FHIT gen