MicroRNAs are small noncoding RNAs that regulate gene expression by targeting messenger RNAs (mRNAs) through translational repression or RNA degradation. Many fundamental biological processes are modulated by microRNAs, and an important role for microRNAs in carcinogenesis is emerging. Because under
Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
β Scribed by ABDEL-RAHMAN N ZEKRI; ABEER A BAHNASSY; MOHAMED HAFEZ; AMAL MR EL-SHEHABY; GHADA M SHERIF; HUSSEIN M KHALED; NADIA ZAKHARY
- Book ID
- 108950042
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 171 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0815-9319
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The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. FHIT has been suggested to be a candidate tumor suppressor gene for digestive tract carcinomas. To ev
Abnormalities of the tumor-suppressor p53 gene have been discovered in human hepatocellular carcinoma (HCC). It is unclear, however, whether HCC related to chronic viral hepatitis is associated with p53 gene alterations. In this study, we have examined p53 abnormalities in HCC associated with hepati
## Abstract Etiological variations in hepatocellular carcinoma (HCC) exist across different geographic areas. To gain better control of HCC, we retrospectively studied the secular trends and geographic variations in hepatitis B virus (HBV)βrelated and hepatitis C virus (HCV)βrelated HCCs in Taiwan.