Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma
β Scribed by Zhongjie Hu; Ryosuke Muroyama; Norie Kowatari; Jinhai Chang; Masao Omata; Naoya Kato
- Book ID
- 108586521
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 171 KB
- Volume
- 100
- Category
- Article
- ISSN
- 1347-9032
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## Abstract The study aims to characterize mutations of the HBV genome involving BCP, Precore/core and X regions and also defines HBV genotypes in patients of hepatocellular carcinoma (HCC). The study involved 150 HBVβrelated HCC cases and 136 HBVβrelated chronic liver disease patients without HCC
We have cloned the whole structural region of the hepatitis C virus (HCV) genome and transiently expressed the nucleocapsid protein in animal cells. Since the nucleotide sequences of this region of the HCV genome has been shown to be highly conserved among different HCV isolates, the assay detecting