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Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer

✍ Scribed by Samuel A Burstein; Anne Dubart; Françoise Norol; Najet Debili; Paul Friese; Tamyra Downs; Xichun Yu; Paul W Kincade; Jean-Luc Villeval; William Vainchenker


Book ID
114217267
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
150 KB
Volume
27
Category
Article
ISSN
0301-472X

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## Abstract ## Background Host immune responses to foreign gene products have been shown to lead to the elimination of genetically modified cells, and are a major barrier to successful therapeutic gene therapy. We have shown that immunological tolerance to retrovirally transduced cell surface prot