Expression of 5-aminolevulinic acid synthase in recombinantEscherichia
โ Scribed by Junqing Wang; Junhui Wu; Zhaoming Zhang
- Book ID
- 106564087
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 320 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1573-0972
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๐ SIMILAR VOLUMES
Endogenous protoporphyrin IX (PpIX), which results from the oral administration of 5-aminolevulinic acid (ALA), is being investigated for its efficacy as a photosensitizing agent for photodynamic therapy (PDT). Clinical use of ALA has been associated with only mild gastrointestinal side effects. The
Aminolevulinic acid synthase 1 (ALAS1) is the rate-limiting enzyme of heme synthesis in the liver and is highly regulated to adapt to the metabolic demand of the hepatocyte. In the present study, we describe human hepatic ALAS1 as a new direct target of the bile acid-activated nuclear receptor farne