𝔖 Bobbio Scriptorium
✦   LIBER   ✦

EVOLUTIONARY CONSIDERATION ON 5-AMINOLEVULINATE SYNTHASE IN NATURE

✍ Scribed by TAMIKO OH-HAMA

Book ID
110238249
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
54 KB
Volume
27
Category
Article
ISSN
1573-0875

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

The role of tyrosine 121 in cofactor bin
The role of tyrosine 121 in cofactor binding of 5-aminolevulinate synthase
✍ Dongwei Tan; Michael J. Barber; Gloria C. Ferreira πŸ“‚ Article πŸ“… 1998 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 545 KB

5-Aminolevulinate synthase (EC 2.3.1.37) is the first enzyme in the heme biosynthesis in nonplant eukaryotes and some prokaryotes. It functions as a homodimer and requires pyridoxal 5'-phosphate as an essential cofactor. Tyr-121 is a conserved residue in all known sequences of 5-aminolevulinate synt

5-Aminolevulinate synthase in sideroblas
5-Aminolevulinate synthase in sideroblastic anemias: mRNA and enzyme activity levels in bone marrow cells
✍ Sylvia S. Bottomley; Mark A. Brandenburg; Helen M. Healy; Brian K. May πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 845 KB

To examine the role of 5-aminolevulinate synthase (ALAS) in the pathogenesis of sideroblastic anemias, levels of mRNAs for erythroid and housekeeping ALAS isozymes were examined, and total ALAS activity was assessed in bone marrow cells. In two patients with X-linked sideroblastic anemia the levels

Effects of hemopexin on heme-mediated re
Effects of hemopexin on heme-mediated repression of 5-aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes
✍ Peter R. Sinclair; William J. Bement; John F. Healey; Nadia Gorman; Jacqueline F πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 623 KB

The serum protein hemopexin is considered to have a major role in the mechanism of the uptake of heme by hepatocytes by means of a heme-hemopexin receptor. Therefore, we examined in primary cultures of adult rat and embryonic chick hepatocytes whether the presence of hemopexin would affect the heme-