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Expression levels of the human DNA repair protein metnase influence lentiviral genomic integration

✍ Scribed by Elizabeth A. Williamson; Jacqueline Farrington; Leah Martinez; Scott Ness; John O'Rourke; Suk-Hee Lee; Jac Nickoloff; Robert Hromas

Book ID
116308943
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
288 KB
Volume
90
Category
Article
ISSN
0300-9084

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## Abstract Repair of some oxidized purines such as 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) is inefficient in human cells in comparison to repair of other major endogenous lesions (__e.g.__ uracil, abasic sites or oxidized pyrimidines). This is due to the poor catalytic properties of hOGG1, the major DNA