Recently, it was reported that the gene expression levels of hepatic cholesterogenic enzymes, including 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and sterol regulatory element binding protein (SREBP)-2, increased in LN-treated male rats (Kojima et al., 2002;Kojima et al., 2004). Since SREBP-2
EXPRESSION LEVEL OF STEROL REGULATORY ELEMENT-BINDING PROTEINS IN A NOVEL RAT MODEL OF METABOLIC SYNDROME
β Scribed by Makiko Kudo-Osawa; Mikiko Matsuyama; Mitsuhide Noshiro; Yuri Aoyama; Yuzo Yoshida
- Book ID
- 108940132
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 147 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0305-1870
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Sterol regulatory element binding protein 1 (SREBP-1) transcription factors play a key role in energy homeostasis by regulating genes involved in both carbohydrate and lipid metabolism, and in adipocyte differentiation. The 5' end of the mRNA-encoding SREBP-1 exists in two forms, designated 1a and 1
## Abstract The role of cyclic adenosine monophosphate (cAMP) is poorly understood in the regulation of normal and abnormal hepatic cell growth. In this study, we examined the regulation of intracellular cAMP levels and its effect on nuclear cAMP responsive elements (CREs) in a rat model of hepatoc