Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats: Correlation with development of hypercholesterolemia
✍ Scribed by Misaki Kojima; Masakuni Degawa
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 136 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0260-437X
- DOI
- 10.1002/jat.1138
No coin nor oath required. For personal study only.
✦ Synopsis
Recently, it was reported that the gene expression levels of hepatic cholesterogenic enzymes, including 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and sterol regulatory element binding protein (SREBP)-2, increased in LN-treated male rats (Kojima et al., 2002;Kojima et al., 2004). Since SREBP-2 is thought to be a common transcription factor for genes of cholesterol biosynthesis enzymes including HMGR (a rate-limiting enzyme in cholesterol biosynthesis (Goldstein and Brown, 1990;Brown and Goldstein, 1997)), LN-induced development of hypercholesterolemia might occur through an increase in the expression level of SREBP-2. In addition, it has been reported that there was sexual dimorphism in hepatic HMGR activity in both rats and mice (Choi et al., 1988;Dupont et al., 1988).
The present study comparatively examined the changes in the gene expression levels of SREBP-2 and HMGR, and in the amounts of hepatic total cholesterol in male and female rats after treatment with LN, and the results are discussed.