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Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer

โœ Scribed by van der Zee, J.A.; van Eijck, C.H.J.; Hop, W.C.J.; van Dekken, H.; Dicheva, B.M.; Seynhaeve, A.L.B.; Koning, G.A.; Eggermont, A.M.M.; ten Hagen, T.L.M.


Book ID
123419154
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
833 KB
Volume
38
Category
Article
ISSN
0748-7983

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## Background: 5-fluorouracil (5-fu) is an anticancer agent clinically used against various cancers including bladder carcinoma. 5-fu inhibits thymidylate synthase (ts) and blocks dna synthesis. ts is the key enzyme in the catalysis of the methylation from deoxyuridine monophosphate (dump) to deoxy