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Expression and glyco-engineering of alpha-galactosidase A in Pichia pastoris for the treatment of Fabry disease

โœ Scribed by De Visscher, Charlotte; Tiels, Petra; Van Hecke, Annelies; Callewaert, Nico


Book ID
122018343
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
59 KB
Volume
108
Category
Article
ISSN
1096-7192

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Fabry disease is an X-linked recessive lysosomal storage disorder caused by a deficiency of a-galactosidase A (a-gal; EC 3.2.1.22). In the past, it has been difficult to give an unequivocal diagnosis of carrier status in Fabry disease because of the overlap between normal and heterozygote enzyme lev