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Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts

✍ Scribed by HORIUCHI, M.; MORINOBU, A.; CHIN, T.; SAKAI, Y.; KUROSAKA, M.; KUMAGAI, S.

Book ID
125478736
Publisher
Journal of Rheumatology Publishing Company
Year
2009
Tongue
English
Weight
398 KB
Volume
36
Category
Article
ISSN
0315-162X

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## Abstract ## Objective Rheumatoid arthritis (RA) is a chronic inflammatory disorder of unknown origin. Histone deacetylase (HDA) activity is considered to play a major role in the transcriptional regulation of proinflammatory genes. We undertook this study to investigate the balance of histone a