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Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans -7,8-Dihydroxy-7,8-dihydrobenzo[ a ]pyrene to the Activated o -Quinone Metabolite Benzo[ a ]pyrene-7,8-dione

✍ Scribed by Burczynski, Michael E.; Harvey, Ronald G.; Penning, Trevor M.


Book ID
125910779
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
5 KB
Volume
38
Category
Article
ISSN
0006-2960

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino