Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFR?) in muscles and spinal cord

✍ Scribed by Xu, Jun ;Forger, Nancy G.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 99 KB
• Volume: 35
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199805)35:2<217::aid-neu8>3.0.co;2-7

✦ Synopsis

We have previously observed that deprivation caused a significant up-regulation of ciliary neurotrophic factor (CNTF) can prevent the CNTFRa mRNA in the BC/LA, thigh, and spinal cord degeneration of androgen-sensitive perineal motoneuof male fetuses. After castration in adulthood, rons and their target muscles, the bulbocavernosus CNTFRa expression in the BC/LA transiently inand levator ani (BC/LA), in perinatal female rats. creased, then decreased below control levels. Expres-Response to CNTF is dependent on the expression sion of CNTFRa in thigh muscles and the lumbosacral of the alpha component of the CNTF receptor spinal cord was not affected by adult castration. Thus, (CNTFRa). In the present study, we examined the the perineal muscles and motoneurons are potential developmental profile and androgen regulation of sites of direct CNTF action, and expression of the CNTFRa gene expression in BC/LA muscle, thigh CNTFRa gene is modulated by androgen, especially muscle, and lumbosacral spinal cord. CNTFRa in the androgen-sensitive perineal muscles. Transient mRNA was abundantly expressed in the BC/LA and up-regulation of CNTFRa following castration or anthigh around the time of birth; expression declined drogen receptor blockade may represent a protective progressively after birth and remained low into adultresponse designed to counteract the muscle atrophy hood. In contrast, CNTFRa message remained high in normally induced by androgen withdrawal. ᭧ 1998 the lumbosacral spinal cord throughout development.