Changes in expression of ciliary neurotrophic factor (CNTF) and CNTF-receptor ? after spinal cord injury

✍ Scribed by Oyesiku, Nelson M. ;Wilcox, Josiah N. ;Wigston, Donald J.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 298 KB
• Volume: 32
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199703)32:3<251::aid-neu1>3.0.co;2-6

✦ Synopsis

To determine if ciliary neuro-CNTFRa, however, the increase in CNTF mRNA was trophic factor (CNTF) is involved in the response to evident both rostral and caudal to the lesion. Levels spinal cord injury, we studied changes in the expression of CNTF and that of its receptor, CNTF-receptor of both CNTF and CNTFRa mRNA declined between a (CNTFRa), in the rat spinal cord after a unilateral 1 and 5 days, and by 10 days they were not signifispinal cord hemisection. Using in situ hybridization, cantly different from normal animals. These findings we found that CNTFRa mRNA levels in spinal cord suggest that CNTF may play a local role in the remotoneurons increased dramatically by 1 day after sponse to spinal cord injury. ᭧ 1997 John Wiley & Sons, hemisecting the spinal cord at T2. This increase in Inc.