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Expression and amplification of therapeutic target genes in retinoblastoma

✍ Scribed by Doris Bösch; Mona Pache; Ronald Simon; Peter Schraml; Katharina Glatz; Martina Mirlacher; Josef Flammer; Guido Sauter; Peter Meyer


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
494 KB
Volume
243
Category
Article
ISSN
0065-6100

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Cyclin D1 is a major positive regulator of the G 1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (