Expression patterns of potential therapeutic targets in prostate cancer
β Scribed by Tobias Zellweger; Christoph Ninck; Michael Bloch; Martina Mirlacher; Pasi A. Koivisto; Heikki J. Helin; Michael J. Mihatsch; Thomas C. Gasser; Lukas Bubendorf
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- French
- Weight
- 681 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Prostate cancer cells rely on androgen receptor (AR) for proliferation and survival. Therefore, curing prostate cancer will require elimination of AR. Although androgen is the natural ligand that activates AR, AR activity is also subject to regulation by growth factor/growth factor rece
## Abstract Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgenβindependent prostate cancer. Recently, increased expression of Idβ1, a basic helixβloopβhelix protein, is reported in several types of advanced cancer. It is suggested that
AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumor development and progression. We wanted to determine (a) whether AKT is overexpressed in human prostatic tumor