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Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes

✍ Scribed by Alessandra Balduini; Alessandro Pecci; Paolo Lova; Nicoletta Arezzi; Carmela Marseglia; Federica Bellora; Cesare Perotti; Cesare Balduini; Carlo L. Balduini; Mauro Torti


Book ID
118505890
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
362 KB
Volume
300
Category
Article
ISSN
0014-4827

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The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder