✦ LIBER ✦

Exploring the mechanisms of antigen processing by cell fractionation

✍ Scribed by Philippe Pierre; Ira Mellman

Book ID: 104358962
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 971 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80242-2

No coin nor oath required. For personal study only.

✦ Synopsis

It is becoming increasingly clear that most of the intracellular compartments that contain MHC class II products in antigen-presenting cells simply represent the conventional endosomes and lysosomes that are expressed in all cell types. Data from recent cell fractionation studies, however, predominantly those using electrophoresis techniques, show that a population of class-II-containing vesicles exists that may comprise a class of endosomes that are specialized for antigen processing. Strong support for this possibility comes from the observation that such specialized structures, designated class II vesicles (GIIV), are particularly abundant in mature dendritic cells.

📜 SIMILAR VOLUMES

Exploring the Mechanisms of Primary Anti

Exploring the Mechanisms of Primary Antibody Responses to T Cell-Dependent Antigens

✍ Mihaela Oprea; Alan S. Perelson 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 323 KB

We have developed a model of the early events that occur during a primary antibody response to a T cell-dependent antigen. Within secondary lymphoid organs, B cell proliferation in response to antigen injection gives rise to two kinds of transient structures: foci that develop in the T cell area, an

Eosinophil as antigen-presenting cell: a

Eosinophil as antigen-presenting cell: activation of T cell clones and T cell hybridoma by eosinophils after antigen processing

✍ Victoria Del Pozo; Belen de Andrés; Elena Martín; Blanca Cárdaba; Julio Cesar Fe 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 794 KB

Mechanisms of Regulatory T-cell Inductio

Mechanisms of Regulatory T-cell Induction by Antigen-IgG-transduced Splenocytes

✍ R. Wang; L. Song; G. Han; J. Wang; G. Chen; R. Xu; M. Yu; J. Qian; B. Shen; Y. L 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB

Contribution of antigen processing to th

Contribution of antigen processing to the recognition of a synthetic peptide antigen by specific T cell hybridomas

✍ Michel Boyer; Zuzana Novak; Arun Fotedar; Bhagirath Singh 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 808 KB

Most antigens recognized by T cells require unfolding or partial degradation (processing) followed by association with Major Histocompatibility Complex (MHC) molecules. We examined the processing requirements for the presentation of antigen to two T cell hybridomas which recognize the alpha-helical

Antigen processing by macrophages: defin

Antigen processing by macrophages: definition of the ligand recognized by T-inducer cells

✍ Joseph Puri; Sara Abromson-Leeman; Harvey Cantor 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 769 KB

An interaction between antigen and macrophage-like cells which display I region gene products [antigen-presenting cells (APC)] is necessary for activation of inducer T cell clones. The specificity of inducer cell activation has been found to be major histocompatibility complex (MHC)-restricted and a

A reassessment of the mechanisms of anti

A reassessment of the mechanisms of antigen-specific T-cell-dependent B-cell activation

✍ Abul K. Abbas 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 882 KB