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Exploring protein fitness landscapes by directed evolution

✍ Scribed by Romero, Philip A.; Arnold, Frances H.

Book ID
109959280
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
506 KB
Volume
10
Category
Article
ISSN
1471-0072

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## Abstract The evolution of our physics‐based computational methods for determining protein conformation without the introduction of secondary‐structure predictions, homology modeling, threading, or fragment coupling is described. Initial use of a hard‐sphere potential captured much of the structu