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Exploration of the ligand binding site of the human 5-HT4 receptor by site-directed mutagenesis and molecular modeling

✍ Scribed by Jeanne Mialet; Yamina Dahmoune; Frank Lezoualc'h; Isabelle Berque-Bestel; Pierre Eftekhari; Johan Hoebeke; Sames Sicsic; Michel Langlois; Rodolphe Fischmeister


Book ID
110005034
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
324 KB
Volume
130
Category
Article
ISSN
0007-1188

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The anatomical localization of 5-HT(4) receptor mRNA and 5-HT(4) receptor protein was examined in sections of post-mortem human brain by in situ hybridization histochemistry and radioligand receptor autoradiography. In the in situ hybridization study, the highest levels of 5-HT(4) receptor mRNA were