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Exploration of the Dopamine Transporter: In Vitro and In Vivo Characterization of a High-Affinity and High-Specificity Iodinated Tropane Derivative (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy- 3β-(4′-methylphenyl)nortropane (PE2I)

✍ Scribed by Denis Guilloteau; Patrick Emond; Jean-Louis Baulieu; Lucette Garreau; Yves Frangin; Léandre Pourcelot; Laurent Mauclaire; Jean-Claude Besnard; Sylvie Chalon

Book ID: 117688232
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 411 KB
Volume: 25
Category: Article
ISSN: 0969-8051
DOI: 10.1016/s0969-8051(97)00224-2

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SUMMARY In order to study the dopamine transporter by \(\mathrm{PET}\), we prepared ( \(E\) )-N-(3-bromoprop-2-enyl)\(2 \beta\)-carbomethoxy-3 \(\beta\)-(4'-tolyl) nortropane (PE2Br) and its radiobrominated analogue. PE2Br and \(\left[{ }^{76} \mathrm{Br}\right] \mathrm{PE} 2 \mathrm{Br}\) were synt