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Exploration of L-Proline-Catalyzed α-Aminoxylation of Aldehyde to ( S )-Guaifenesin-Related Drug Molecules

✍ Scribed by Panchgalle, Sharad P.; Kunte, Sunita S.; Chavan, Subhash P.; Kalkote, Uttam R.

Book ID: 120323327
Publisher: Taylor and Francis Group
Year: 2011
Tongue: English
Weight: 285 KB
Volume: 41
Category: Article
ISSN: 0039-7911
DOI: 10.1080/00397911.2010.493631

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ChemInform Abstract: Exploration of L-Proline-Catalyzed α-Aminoxylation of Aldehyde to (S)-Guaifenesin-Related Drug Molecules.

✍ Sharad P. Panchgalle; Sunita S. Kunte; Subhash P. Chavan; Uttam R. Kalkote 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 39 KB

## Abstract The title reaction leads to enantiomerically pure guaifenesin (II) which is used for the preparation of (S)‐(‐)‐moprolol (V) and (R)‐(+)‐methocarbamol (VIII).