ChemInform Abstract: Exploration of L-Proline-Catalyzed α-Aminoxylation of Aldehyde to (S)-Guaifenesin-Related Drug Molecules.

✍ Scribed by Sharad P. Panchgalle; Sunita S. Kunte; Subhash P. Chavan; Uttam R. Kalkote

• Book ID: 102066001
• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 39 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201201189

✦ Synopsis

Abstract

The title reaction leads to enantiomerically pure guaifenesin (II) which is used for the preparation of (S)‐(‐)‐moprolol (V) and (R)‐(+)‐methocarbamol (VIII).