Experiments on the synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues
β Scribed by Sugasawa, Tsutomu; Toyoda, Tatsuo; Uchida, Naomi; Yamaguchi, Kenji
- Book ID
- 127235904
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 672 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2623
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Novel water-soluble camptothecin analogues with excellent antitumor activity have been designed and synthesized by total synthesis. The analogues were evaluated for cytotoxic activity against five tumor cell lines. The most potent analogue 6e exhibited significant antitumor activity at wider range o
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