Caffeine induces cardiac and other malfo
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Matsuoka, Rumiko ;Uno, Hideo ;Tanaka, Harumi ;Kerr, Clare S. ;Nakazawa, Kazuharu
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Article
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1987
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John Wiley and Sons
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English
⚖ 739 KB
At various gestational periods, caffeine was injected intra-arterially or intraperitoneally into pregnant rats. The teratogenic effects of caffeine on the fetal heart were dose dependent and detectable at relatively low concentrations. The most susceptible stage was during septation of the heart. Th