𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Caffeine induces cardiac and other malformations in the rat

✍ Scribed by Matsuoka, Rumiko ;Uno, Hideo ;Tanaka, Harumi ;Kerr, Clare S. ;Nakazawa, Kazuharu ;Nadal-Ginard, Bernardo ;Opitz, John M. ;Bernstein, Jay

Book ID
102699737
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
739 KB
Volume
28
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

At various gestational periods, caffeine was injected intra-arterially or intraperitoneally into pregnant rats. The teratogenic effects of caffeine on the fetal heart were dose dependent and detectable at relatively low concentrations. The most susceptible stage was during septation of the heart. The most common cardiovascular malformation was ventricular septa1 defect. Extracardiovascular anomalies, such as decreased thymic weight and degeneration of the lens, were found in all fetuses; skeletal malformations were found in some fetuses.

πŸ“œ SIMILAR VOLUMES

Hypoxia induces cardiac malformations vi
Hypoxia induces cardiac malformations via A1 adenosine receptor activation in chicken embryos
✍ Satish K. Ghatpande; Charles J. Billington Jr; Scott A. Rivkees; Christopher C. πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 951 KB

## Abstract ## BACKGROUND: The current understanding of the effects of hypoxia on early embryogenesis is limited. Potential mediators of hypoxic effects include adenosine, which increases dramatically during hypoxic conditions and activates A~1~ adenosine receptors (A~1~ARs). ## METHODS: To exam