✦ LIBER ✦

Experimental paracetamol-induced hepatic necrosis: A histopathological study

✍ Scribed by M. F. Dixon; J. Nimmo; L. F. Prescott

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 652 KB
Volume: 103
Category: Article
ISSN: 0022-3417
DOI: 10.1002/path.1711030404

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

HEPATIC necrosis resulting from massive overdosage with paracetamol (N‐acetyl‐p‐aminophenol, acetaminophen, APAP) was first reported in rats by Boyd and Bereczky in 1966. A report of this complication in man soon followed (Davidson and Eastham, 1966) and a total of 12 such cases have now been reported (Thomson and Prescott, 1966; Maclean et at., 1968; Pimstone and Uys, 1968; Rose, 1969; Toghill et al., 1969). Whilst Boyd and Bereczky were mainly concerned with acute oral toxicity, they summarised the histopathological findings in a large number of tissues and gave a brief description of the histological changes in the liver. There has not been a detailed histopathological study of paracetamol‐induced liver necrosis, nor has the natural course of the lesion been adequately described. The main objective of the present study was to provide such information by examining the changes in the livers of rats killed at various intervals after administration of a single large dose of paracetamol.

📜 SIMILAR VOLUMES

Inhibition of tumour necrosis factor alp

Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis

✍ Simpson, Kenneth J.; Lukacs, Nicholas W.; McGregor, Angus H.; Harrison, David J. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

Paracetamol-induced hepatic necrosis is the most common form of toxic liver injury experienced in clinical practice in the UK and USA. Recently, reports have described prevention of hepatic necrosis, induced by other hepato-toxins, by inhibiting tumour necrosis factor alpha (TNFalpha). The aim of th

Dose-dependent actions of curcumin in ex

Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence

✍ Vineeta Tanwar; Jaspreet Sachdeva; Kamal Kishore; Rajan Mittal; Tapas Chandra Na 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB 👁 1 views

Galactosamine-induced fulminant hepatic

Galactosamine-induced fulminant hepatic necrosis in unanesthetized canines

✍ J A Diaz-Buxo; S Blumenthal; D Hayes; P Gores; B Gordon 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB

Abbreviations: FHF, fulminant hepatic failure; IV, intravenous; AST, aspartate transtaneous cannulation with polyurethane single lumen catheters (Medaminase; ALT, alanine transaminase; PT, prothrombin time; PTT, partial thromboplastin time. Comp MCF10, Harleysville, PA), using the Seldinger techniq

Congenital hydrocephalus: A new experime

Congenital hydrocephalus: A new experimental model with histopathological study

✍ G. Di Trapani; G. G. Garzetti; A. La Cara; L. C. R. Pentimalli 📂 Article 📅 1990 🏛 Springer Milan 🌐 English ⚖ 633 KB

Hepatic arterial infusion of human recom

Hepatic arterial infusion of human recombinant tumor necrosis factor-alpha. An experimental study in dogs

✍ Shin-Ichi Ohkawa; Kenneth C. Wright; Harsh Mahajan; Giora M. Mavligit; Sidney Wa 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 694 KB

Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and

The histopathology of congenital pneumon

The histopathology of congenital pneumonia: A clinical and experimental study

✍ Barter, Robert 📂 Article 📅 1953 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 821 KB