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Experimental metastasis is suppressed in MMP-9-deficient mice

โœ Scribed by Takeshi Itoh; Masatoshi Tanioka; Hidetoshi Matsuda; Hirofumi Nishimoto; Takayuki Yoshioka; Ryuji Suzuki; Masahiro Uehira


Book ID
110238538
Publisher
Springer
Year
1999
Tongue
English
Weight
70 KB
Volume
17
Category
Article
ISSN
0262-0898

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## Abstract Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatm